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A critical review indicates that while GLP-1 receptor agonists do promote weight loss, the numbers in real-world settings are modest compared to the transformation narrative so widely circulated
Insulin resistance is the inadequate response of target tissues to the physiological effects of circulating insulin, such as decreased glucose uptake in skeletal muscles under insulin stimulation, inhibition of hepatic gluconeogenesis by insulin, and relief of the inhibitory effect of insulin on lipid breakdown in adipose tissue (Schenk et al., 2008)
Weight changes were minimal and not significantly different from placebo [71]
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2008 May 15;453(7193):314-21
LDL Cholesterol The LDL story with tirzepatide is positive but more moderate than the triglyceride effect
