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This concern is a common theme in neurodegenerative disease treatment, when disease-modifying therapies are often considered to be effective only, or mainly, in the early stages of the degenerative process

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PMID 1540595

It behaves like a very effective fat-loss tool with the same lean-mass caveat every rapid weight-loss intervention carries

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In order to optimize free T3 levels you will want to do the following: Take supplements that increase T4 to T3 conversion like zinc , selenium , and B6 Get off of medications (if possible) that block (8) T4 to T3 conversion like antidepressants, narcotics, mood stabilizers, pain modulators, blood pressure medications, and diabetic medications