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Yes, persistent or worsening fatigue despite GLP-1 treatment warrants medical review to investigate other potential causes such as anaemia, thyroid disorders, sleep apnoea, depression, or medication side effects

The authors thank Figdraw for providing drawing support

Systemic Impact: This functional iron deficiency leads to reduced physical performance, cognitive decline, and increased all-cause mortality in elderly populations

But without a plan, GLP-1s can quietly become your biggest prescription care expense

Reduced SCFA production means less GLP-1 stimulation from L-cells