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Published data suggests up to 2.6% incidence of B12 deficiency within a year of treatment, and this figure climbs in patients who have used these medications long term or combined them with very low calorie diets (3)

But if you have sensitive skin or have a known facial dermatosis, you may want to take additional precautions and consult your dermatologist beforehandespecially if you are just getting started

Bacosides from Bacopa monnieri extract: An overview of the effects on neurological disorders

DOI: 10.3389/fnagi.2010.00012 53

Many peptides are not approved by regulators, and their safety, purity, and interactions are not well established