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Janus kinase (JAK) blocker Tofacitinib, a JAK blocker, accelerated bacterial elimination in a preclinical study when administered at high doses alongside standard TB chemotherapy in chronic M.tb -infected BALB/c mice

These unfolded/misfolded proteins remain within the endoplasmic reticulum (ER) lumen leading to excessive ER stress which is detrimental for cell survival 7

B12 deficiency may result from a vegetarian or vegan diet, as B12 naturally occurs in animal foods

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Absorption is improved for optimal effectiveness

This increases oxygen and nutrient delivery to damaged joints, accelerating recovery and reducing inflammation