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Blitzer et al., 2021), and diabetic retinopathy (Maleki et al., 2017

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With its localization to the SR, nNOS regulates the S-nitrosylation of the calcium release channels, the type 2 ryanodine receptors (RYR2) resulting in release of stored calcium, The localization of nNOS in the plasma membrane allows for direct S-nitrosylation of L-type Ca 2+ channels resulting in increased influx of calcium

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To mitigate this issue, current tick control programs recommend rotating acaricides to reduce the emergence of a resistant tick strain 16

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While its effective for controlling blood sugar in people with type 2 diabetes, most people wont lose a meaningful amount of weight while taking it

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