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On the contrary, some HSV-1-induced H2AX foci were still detected in neurons infected in the presence of PAA (Figures 2B,d,h) that blocks viral DNA synthesis, but not transcription of early genes, suggesting that viral DNA replication is not essential but may partly contribute to the accumulation of H2AX

The value is a starting point, not a diagnosis, and its meaning depends on the exposure history, the trend over time, the symptoms, and the other laboratory findings around it

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Around 30 years of age, estrogen levels begin to decline, and there are corresponding changes in the skin

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