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Notably, high-dose LEO (60 mg/kg) markedly elevated acetic acid and isobutyric acid levels, whereas butyric acid exhibited a robust increase even at the lower dose (30 mg/kg), with further enhancement at 60 mg/kg (Figures 3AF)

Therefore, this report represents the first documented prolonged water fast for a patient with morbid obesity (BMI 40) since 1973, when Angus Barbieri lost 276 pounds (82 kg) over 382 days [10]

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