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11 Patients likely to benefit from these medicines who do not meet the criteria for funded treatment are those: 11 With CVD (or five-year CVD risk 15%), renal disease or heart failure * with a HbA 1c 75 mmol/mol do not usually require a reduction in insulin or sulfonylurea, unless they have a history of hypoglycaemia

2 Section of Nephrology, Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA

The cells were incubated at room temperature for 30 minutes in the dark, and the cell cycle was analyzed by flow cytometry (Win Bryte HS cytometer [Bio-Rad], using software Win Bryte, Bio-Rad Laboratories Inc., Hercules, CA, USA)

Acknowledgements This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (RS-2023-00245453)

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This gives it enough time to exert its effects while preventing the system from overcorrecting