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Cooke, M.E., et al

Vitamin B12 deficiencies affect the way in which our bodies use valuable energy

Second, the strength of tirzepatides evidence is exactly what makes an apples-to-apples ranking against an investigational amylin analog impossible: you cannot fairly rank a fully-approved drug against a candidate whose stand-alone efficacy stops at Phase 2

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So the benefit is real, but it is indirect and it depends on whether you were low to begin with