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Jastreboff AM, Kaplan LM, Frias JP, et al
primer for the pathway-level background
That's your first real due-diligence checkpoint
So, lets take a closer look at each one individually
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Receptors are the big one: tirzepatide runs GLP-1 plus GIP, retatrutide runs GLP-1 plus GIP plus glucagon
In plain terms, semaglutide hits one target, Tirzepatide hits two, and retatrutide hits three
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