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OA-causing factors such as age and mechanical stress lead to excessive oxidative stress in chondrocytes 37,38

The LR3 modification extends the peptides half-life in circulation, making it significantly more stable and active than native IGF-1

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Acknowledgments This work was supported by the National Natural Science Foundation of China (grant 81670336) and the Wenzhou Grant for Scientific Talents (RX2016003), Wenzhou Science and Technology Bureau