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Increased FFA in the liver results in insulin resistance, hepatic glucose production, and pancreatic beta cell dysfunction [7]
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In contrast to GIP, GLP-1 was found to retain its insulinotropic effect in patients, and this fact provides part of the background for the clinical use of GLP-1 receptor agonists in diabetes treatment
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Patients with T2DM experience a significant decline in the incretins functional properties which causes delayed and reduced insulin release after glucose administration and impairs glucose tolerance [12,13,14]
Eur J Obst Gynecol Reprod Biol
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