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Much of the clinical work with DSIP has been small scale, in specific populations (e.g., chronic insomniac patients, disturbed human sleep), and sometimes with injections in hospital/lab settings
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Clinical evidence shows that stopping GLP-1 therapy usually leads to weight regain and worsening blood sugar control
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Astrocytic endfeet appear swollen under certain pathological conditions such as ischemic stroke [50], which has been associated with changes in osmotic homeostasis in response to the release of factors such as L-glutamate of K + from parenchymal brain cells
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