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Title : Use of GLP1-RAs in patients with a history of cholelithiasis Author: Sarah Hughes, PharmD Candidate 2024 University of Rhode Island, School of Pharmacy Reviewer: Courtney Cameron, PharmD, BCACP Background Cholelithiasis, also known as gallstones, are hardened collections of bile materials such as cholesterol or bilirubin that collect at the bottom of the gallbladder
When considering the function of gut-derived GLP-1, it is difficult to ignore the metabolic effects of nutrient-derived energy in addition to the direct actions of GLP-1 itself
These typically include nausea, vomiting, diarrhoea, constipation, abdominal discomfort, and reduced appetite
with its unique mechanism of action