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One criticism is that syringes are too big at 3ml and ga, should be insulin 100iu needles

Many people ignore it for years until symptoms become severe

An earlier 12-week trial in 300 obese adults produced a genuine positive signal the 1 mg daily dosing arm showed a statistically significant 2.8 kg mean weight loss versus 0.8 kg in the placebo group and that result is what justified moving into the larger Phase IIb trial

Cold Spring Harbor Perspectives in Biology, 3 (12), Article a005058

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