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The authors met five times to review the retrieved evidence, discuss key concepts, and ensure consistent incorporation of predetermined core themes throughout the manuscript

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Specifically, animal studies show MPs can disrupt the -diversity of gut microbiota and decrease the Firmicutes-to-Bacteroidetes (F/B) ratio, resulting in an increased relative abundance of pathogenic bacteria in ICR mice (Wang et al., 2002), which are critical factors in the pathogenesis of neurodegenerative diseases

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They often reflect the combined effect of hormonal shifts alongside reduced antioxidant and detoxification capacity

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