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Levels decline with age and drop further in chronic disease, including Parkinson's disease, liver disease, heart disease, and alcohol use disorder
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Preclinical efficacy studies across molecularly distinct breast cancer subtypes demonstrated remarkable potency with sub-micromolar IC values between 1.96 and 4.54 g per milliliter against both MCF-7 luminal and MDA-MB-231 triple negative cells, while sparing normal HUVEC endothelial cells, validating the tumor selective activation mechanism
Grasselli E, Voci A, Demori I, De Matteis R, Compalati AD, Gallo G, et al