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Nevertheless, the present study still has some limitations, as the current study has not yet externally validated our proposed risk stratification model, its clinical application still needs to be validated in external cohorts, including retrospective cohorts from other centers and future prospective multicenter cohorts
Likewise, studies have shown that no dose adjustment of liraglutide or semaglutide is needed in patients with renal deficiencies (135, 136)
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this reduces depletion of muscle glycogen
Total: 2 injections per week with complementary effects
For those who do not tolerate 0.25 mg weekly (19 clicks, the usual starting dose) we may try them on 5 or 10 clicks weekly
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