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CRISPR-Cas9 in vivo gene editing for transthyretin amyloidosis
Subcutaneous injection offers bioavailability of approximately 15-20% based on animal data, while intramuscular administration may provide 45-50% bioavailability in some species
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Hardwick Supplementary information Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made
What you need on hand: The lyophilized peptide vial The correct solvent (the one named on the certificate of analysis) A fresh sterile syringe and needle for each draw Alcohol wipes and an alcohol-wiped work surface A labeled storage spot at 2 to 8C The full sequence, start to finish: Bring the sealed peptide vial and solvent to room temperature so condensation does not cloud the solution
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