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While the classical incretin concept is based on the assumption that incretin hormones such as GIP and GLP-1 reach their main endocrine target cells via the bloodstream, there is some evidence that GIP (and possibly GLP-1) can be produced in relatively small amounts in endocrine alpha-cells of the pancreas [3]

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The effect is dose-dependent: higher doses are more likely to trigger symptoms, which is why slow dose escalation is the standard medical approach

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