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Am J Hum Genet (2019) 105:23757

We keep a close eye on how patients react to treatment and adjust the dose as needed

Methods Mice We obtained mice with Nestin-Cre recombinase fused to a mutated estrogen receptor ( Nestin-Cre ER ) in a C57BL/6 background, ROSA26-EYFP in C57BL/6 background, and Igf1r with loxP sites flanking exon 3 ( Igf1r fl/fl ) mice in a mixed C57Bl/6 129 background from the Jackson Laboratory

It is naturally produced in nearly every cell of the body and plays a central role in: Neutralizing free radicals that cause oxidative stress and cellular damage Supporting liver detoxification , particularly in Phase II detox pathways Regulating the immune system , helping balance inflammation and defense Repairing DNA and proteins , essential for anti-aging and longevity Because of its central role in cellular defense, glutathione is often called the master antioxidant. However, levels can drop due to aging, chronic stress, poor diet, toxin exposure, or genetic variants like MTHFR , which can limit glutathione recycling

Naturally produced by the body, its most concentrated in the liver, where it performs several essential tasks: Neutralizing free radicals and oxidative stress Assisting in detoxification pathways Regulating immune response Aiding in cell repair and regeneration As we age or face chronic stress, poor diets, pollution, or alcohol use our natural glutathione levels decline

doi: 10.1038/nm.1968 130 ChandrasekharSYuXPHarveyAKOskinsJLLinCWangXet al