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Hydration is also important, since appetite suppression can reduce the incidental hydration that comes from eating water-rich foods
Practically it provides a convenient N-terminal leader for bacterial expression, which is part of why this construct became the standard reagent rather than a laboratory curiosity
LIR is suitable to be administered once a day, with a t max of 9~13 hours and t 1/2 of 13 hours ( Compared with the treatment of short-acting GLP-1R agonists, LIR has a greater improvement in lowering glycated hemoglobin and fasting blood glucose
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