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Results typically become noticeable within a few weeks, depending on the specific peptide used and individual response
Conversely, GLP-1 analogues are associated with a higher incidence of gastrointestinal adverse events compared to sitagliptin: nausea (relative risk 3.14, 95% CI 2.15 to 4.59), vomiting (relative risk 2.60, 95% CI 1.48 to 4.56), diarrhea (relative risk 1.82, 95% CI 1.24 to 2.69), and constipation (relative risk 2.50, 95% CI 1.33 to 4.70)
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A recent study underscored that dapagliflozin and/or liraglutide attenuated cardiac tissue injury via reducing key elements of oxidative stress, inflammation and apoptosis in diabetes-induced cardiomyopathy rats [62]
In certain cases, providers may consider combination protocols
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