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USE IN PATIENTS WITH HEPATIC IMPAIRMENT One clinical trial has been published assessing the safety, tolerability, and pharmacokinetics of oral semaglutide in patients with hepatic impairment

OMP continues to be converted into orotidine monophosphate (UMP) and then uridine triphosphate (UTP), which is then converted into CTP by cytidine triphosphate synthetase (CTPS) via utilizing the amide group on glutamine (Figure 1)

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If they do, that means dulaglutide, the active ingredient in Trulicity, could cause blood clots and DVT