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However, this approach has also impacted Type 2 diabetes patients access to GLP-1s by requiring some patients to try other diabetes treatments (e.g., blood sugar regulators such as sodium-glucose cotransporter-2 inhibitor Brenzavvy and dipeptidyl peptidase-4 inhibitor Onglyza) before GLP-1 approval
Based on the typical UK regulatory pathway, the most realistic timeline is: Late 2026 / early 2027: Eli Lilly expected to submit regulatory filings to the FDA and MHRA following completion of the remaining TRIUMPH Phase 3 readouts Late 2027 to mid-2028: Possible MHRA marketing authorisation, allowing private UK prescribing 2028 to 2029 onwards: Possible NHS availability following a NICE technology appraisal and NHS commissioning decisions Timelines may differ across the four UK nations, as Scotland, Wales, and Northern Ireland assess medicines separately through the Scottish Medicines Consortium (SMC), All Wales Medicines Strategy Group (AWMSG), and the Department of Health Northern Ireland respectively
doi:10.5665/sleep.4408
GLP-1RAs can suppress foam cell formation by activating GLP-1R signaling induced autophagy [134], reducing ACAT1 expression/activity [93], as well as inhibiting the PKA/CD36 pathway to inhibit ox-LDL uptake [135]
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