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Additionally, the FDA recommends that these medications not be taken during pregnancy and be discontinued at least two months prior to pregnancy, because studies in rats, rabbits, and monkeys demonstrated that animals treated with these medications had higher rates of miscarriage, were born smaller, and were more likely to have birth defects

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Matveyenko AV, Dry S, Cox HI, Moshtaghian A, Gurlo T, Galasso R, Butler AE, and Butler PC

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Although most (96%) felt that screening was important, screening frequency varied among providers with 90% APP screening at most/every visit compared to faculty and fellows (56% vs 50%, p=0.04)

It is produced and secreted by intestinal enteroendocrine L-cells and certain neurons within the nucleus of the solitary tract in the brainstem upon food consumption