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The mechanism of action centers on mimicking endogenous GLP-1, an incretin hormone secreted by intestinal L-cells in response to nutrient intake
Rybelsus (semaglutide) is an oral GLP-1 receptor agonist licensed for type 2 diabetes treatment in the UK The most common side effects are gastrointestinal symptoms including nausea, vomiting, diarrhoea, and abdominal pain Tiredness may result from reduced calorie intake, dehydration from gastrointestinal effects, or blood glucose fluctuations Hypoglycaemia risk increases when Rybelsus is combined with sulphonylureas or insulin Persistent or severe fatigue warrants medical assessment to exclude complications, nutritional deficiencies, or concurrent conditions Report suspected side effects through the MHRA Yellow Card scheme to support medication safety monitoring Table of Contents Can Rybelsus Make You Tired
doi: 10.3389/fpsyt.2019.00808 203 NaganoTLublingYStevensTJSchoenfelderSYaffeEDeanWet al
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Regular monitoring by healthcare professionals may ensure safety and effectiveness throughout the treatment period
