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The active-site cavity, which is located between the two domains, comprises a glutathione binding site (G-site), formed mainly by the N-terminal domain, and a hydrophobic substrate-binding site (H-site), which is formed by the C-terminal domain

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Glutathione is considered the "master antioxidant." It not only fights free radicals and supports the body's detoxification pathways, it also helps to replenish antioxidant vitamins C and E

77, (New York, Academic Press, Inc., 1981), p