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it is a documented clinical observation requiring dermatological monitoring
The entire hemodynamic balance is deregulated by the activation of the renin-angiotensin system, the occurrence of hydro-electrolytic and acid-base imbalances, and peripheral edema, localized or generalized, which affect vital organs such as the nervous system, osteoarticular apparatus, liver, lung parenchyma, and cardiovascular system ( Table 1 Main complications in the evolution of NS ( In the extensive process described previously, the systemic pro-oxidative status appears to be the central driver of the vicious cycle
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TML undergoes a series of enzymatic reactions, including -N-trimethyl-lysine hydroxylase (HTMLA), -butyryl transferase (BBOX), etc., and is finally converted into L-carnitine
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