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The findings deliver early evidence that semaglutide may offer a dual benefit, targeting obesity and key reproductive challenges associated with the condition, including irregular menstruation and impaired fertility. Clare Thompson, MBBS, BSc, nMRCGP Separately, a review of five randomized controlled trials presented at ENDO 2026 found that GLP-1 drugs, such as semaglutide and liraglutide, do not appear to harm male fertility and may even improve testosterone levels and sperm quality in some men with obesity

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[1] [2] : 268 GGT plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione as well as drug and xenobiotic detoxification

Dr Henrik Sillesen, chief medical officer of Airfinity, a UK-based health analytics provider, said a trial like SURMOUNT-5 has the potential to give Eli Lilly an edge over its Danish competitor

Whether you decide to go forward with taking a GLP-1 for weight loss or not, remember that making healthy lifestyle choices, like eating a balanced diet and staying active, will play a large role in your individual progress