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As your estrogen levels do a nosedive, this abdominal fat goes from about 5 to 8 percent of your total body weight to as much as 15 percent of your total body weight

But if it persists, you may want to seek medical attention: For most people, fatigue improves as their body adapts to the medication, he says

While this exhaustion is usually temporary and most intense during the first 4 to 8 weeks of treatment, it can be managed by prioritizing high-quality protein, maintaining electrolyte balance, and ensuring you do not drop below a healthy calorie limit

It also sits on a solid research base, with work exploring how it binds and signals at melanocortin receptors (Sawyer et al., 1980)

How much weight can you actually lose on semaglutide

Split doses (morning and evening) maintain more stable levels for intensive protocols