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When MTHFR diverts 5,10-MTHF to 5-MTHF production, less 5,10-MTHF is available for TYMS reducing dTMP synthesis and causing the intracellular dUTP/dTTP ratio to shift toward excess dUTP

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IV delivery allows all of these nutrients to reach peak blood levels simultaneously, supporting the antioxidant recycling chain

84(5): 62733 Sahajwalla CG, Helton ED, Purich ED, et al