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Weight loss alone may no longer justify premium positioning in a market where semaglutide costs $245 per month

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The absolute dosing regardless of body mass likely increased the variability of response within supplementation groups thereby limiting the findings of the present study

[17] Although animal and cellular models suggest that ALCs on neurotransmitter regulation, improvement in dysfunctional neuroplastic changes, and membrane modulation may play important role in the treatment of depression, more controlled trial data with adequately-powered, well-designed, and advanced methodology should be performed to conclude whether ALC as a monotherapy or supplementation agent may be clinically beneficial for MDD

2021;12:721198 Ethics declarations Competing interests The authors declare no competing interests