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All participants were on metformin at the maximum tolerated dose according to clinical and laboratory parameters (mean dose = 1500 mg), and none were taking other antihyperglycemic drugs including insulin analogues
Enriched environment treatment reverses depression-like behavior and restores reduced hippocampal neurogenesis and protein levels of brain-derived neurotrophic factor in mice lacking its expression through promoter IV
1 Cesarone MR et al
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The items below reflect a mix of what the research suggests and what patients commonly describe in clinical practice
"When you take the next dose, it hits your system like a ton of bricks because your body has lost its tolerance
