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Description

This was determined in ChimeraX by aligning the two D1 lobes and utilizing the measure rotation command ( Pore sizes for each structure were calculated using the program HOLE, and the corresponding figures were generated in PyMOL

Statistical analysis was performed by determining log ( / K A ) for each agonist and experiment, and propagating error from average log ( / K A ) from several experiments to calculate 95% confidence intervals (CI)