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Controlled study of induced granulomas treated with NAC showed 2-fold increase in GSH, 3-fold increase in Interferon-, 2- and 3-fold reduction in tumor necrosis factor- (TNF-) at 8 and 15 days, reduced reactive oxygen ions and reduced necrosis as compared to controls (68)
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In the current study, glutathione treatment significantly decreased ferritin levels, but the mechanism behind the decrease remains unclear
Zhao LJ, Subramanian T, Zhou Y, Chinnadurai G
Remarkably, neonatal exposure to commensal microbes is required to mitigate this susceptibility (87)
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