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IV use could also be needed when there are gastrointestinal complications leading to the need for the liquid to bypass the stomach
According to British Society for Haematology (BSH) guidelines and NICE Clinical Knowledge Summaries (CKS), the primary beneficiaries include: Key patient groups who may require B12 injections include: Pernicious anaemia patients requiring lifelong hydroxocobalamin 1mg intramuscularly every 23 months following initial loading doses Patients with gastrointestinal disorders including those who have undergone gastrectomy or ileal resection, and patients with conditions affecting B12 absorption such as Crohn's disease or coeliac disease Strict vegans and vegetarians though oral supplementation is usually sufficient unless malabsorption is present Elderly patients who may have reduced gastric acid production affecting B12 absorption Patients taking certain medications including metformin (MHRA advises monitoring B12 levels in long-term users, particularly those with risk factors or symptoms), proton pump inhibitors, and H2-receptor antagonists long-term [6] Individuals with neurological symptoms such as paraesthesia, ataxia, or cognitive impairment related to B12 deficiency Pregnant women with confirmed deficiency (hydroxocobalamin for malabsorption
It helps ease symptoms like tiredness, weakness, and neurological problems
Yet, the body's response can vary widely
Six Phase I/II clinical trials enrolling approximately 900 participants confirmed an excellent safety profile with no serious adverse events attributed to the compound
[23] The duration of therapy (number of weeks or months of injections) is also determined on a case-by-case basis
