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European Journal of Clinical Nutrition , 68 (5), 541548

Transferrin receptor 1 nuclear translocation facilitates tumor progression via p53-mediated chromatin interactions and genome-wide alterations

The relationship between dose and effect follows a sigmoid curve, meaning small potency losses at certain dose points might barely matter while the same percentage loss at other points could significantly reduce effectiveness

Our preliminary interpretation is that replacement of Tyr110 indeed affects the interaction with GSH but, as compared to K105A/Y, does not drastically alter the ratio between the steady-state concentrations of the deprotonated and glutathionylated enzyme species E and F, respectively

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