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Regulatory Context: Afamelanotide (marketed as Scenesse) is FDA-approved for the treatment of erythropoietic protoporphyria (EPP)
This suggests that MT-3s main function in fat tissue is the same as that of astrocytes in the brain, which protect this tissue from hypoxic damage
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Recent studies of global and tissue-specific gene KO mice indicate that IGF-I signaling is more critical in the latter steps of the process, but less in the skeletal patterning
6 , e13651 (2018)
Anesth Analg 136(4):628635
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