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Discovered in human plasma, GHK-Cu levels decline significantly as we age which is why replenishing it can have powerful anti-aging and restorative effects
The animal literature is unusually consistent, though: nearly every published in vivo study used 5 mg/kg per injection, given three times on alternate days (days 1, 3, and 5, or days 14, 16, and 18 in the pulmonary fibrosis model), with effects tracked over the following three to four weeks
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That said, infusions of glutathione do help protect against UV-induced oxidative damage in skin cells and support collagen integrity - so no matter the specifics, your skin will benefit
Cycling is recommended for injectable GHK-Cu to manage cumulative copper exposure, even though standard doses are well below the toxic range
Interestingly, they found aberrations in ROS clearance pathways, including elevated glutathione levels, decreases in mitochondrial superoxide dismutase levels, and glutathione peroxidase 4 mediated lipid oxidative damage
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