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GHs anabolic support at the muscle level means that the same training stimulus produces better lean mass maintenance and often modest strength improvement relative to the pre-protocol baseline
Ensuring adequate protein intake, maintaining nutritional supplementation, and avoiding excessive caloric restriction during transitions can help minimize this risk
In addition to its antioxidant function, GSH contributes to detoxification through its role in conjugation reactions catalyzed by glutathione S-transferases (GSTs), thereby preventing the accumulation of neurotoxic metabolites and supporting neuronal integrity
This review aims to fill these gaps by offering a comprehensive assessment of GSHs dual role in cancer biology, systematically examining nanotechnology-enabled approaches (such as disulfide and diselenide linkages, transition metal systems, and prodrugs), and critically evaluating their strengths, limitations, and potential for clinical translation
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