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The activated cPLA2 complex also binds to the lysosomal membrane and facilitates the release of enzymes that damage organelle membranes, leading to mitochondrial damage, organelle degradation and cell death associated with secondary injury [82]

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It could be expected that abrupt arousal may have led to enhanced breathing but as this did not appear to happen it is likely that GSHee interacted directly with the neural pathways/cellular mechanisms responsible for fentanyl-induced OIRD

They are not held to the same purity, sterility, or potency standards as medications intended for human administration

283 From a theoretical perspective, systems biology provides a quantitative framework to interpret these emergent behaviors

Supports DMPK, toxicology, and follow-up studies on bioactivation pathways