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PSMA also has an internalization signal via its MXXXL cytoplasmic tail motif: upon binding, antibody-PSMA complexes undergo internalization from the cell surface into endosomal compartments via clathrin-coated pits, where the unique microenvironment facilitates the release of ADC payloads 69

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doi: 10.1089/thy.2007.0234 207 RizzoMRossiRTBonaffiniOSciscaCAltavillaGCalboLet al

It also has anti-inflammatory properties that soothe irritated skin and manage an even skin tone