Both IDH1 and IDH2 enzymes utilize NADP + as their cofactor and generate NADPH via oxidative decarboxylation of isocitrate outside the context of the TCA cycle
Exposure to outdoor elements, primarily ultraviolet (UV) irradiation and oxidative stress is the main cause for photoaging
Improved insulin sensitivity: A 2022 trial found 500 mg daily for 6 months lowered HbA1c in elderly diabetics
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This antioxidant action helps protect against oxidative stress, which is implicated in various health issues and accelerated aging