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Many patients do well long-term at 5 to 10 mg tirzepatide or 1.0 to 1.7 mg semaglutide
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5 GLP-1/GIP agonists have demonstrated the ability to significantly reduce body weight by up to 15% or more in patients
By contrast, 7-hydroxymitragynine (7-OH), while also labeled a partial agonist, is highly potent at the same receptors and produces dose-dependent respiratory depression and dependence signals in animal studies
Yet, when someone with B12 deficiency reports that symptoms re-occur 4-5 weeks after a B12 injection, and wants to inject more often, all of a sudden, this person is mislabelled as suffering from the placebo effect of B12 injections
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