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Tirzepatide as a monotherapy represents another pathway forward, with an FDA-approved maximum dose of 15mg weekly that exceeds semaglutide's ceiling
Possible side effects depend on the peptide and dosage but may include nausea, flushing, headache, high blood pressure spikes, or skin changes (especially with melanotan II)
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The result is sudden, irreversible vision loss
246 To address this issue, ongoing trials such as MUSIC-HFrEF (NCT04703842) and MUSIC-HFpEF (NCT06061549) are exploring the use of patented titration techniques to optimize dosage, aiming to achieve therapeutic efficacy while minimizing adverse effects
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