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However, limitations included the restricted inclusion criteria (eGFR range of 2075 mL/min/1.73 m 2 and albuminuria requirements), which limit generalizability to patients with higher or lower eGFR or preserved eGFR without albuminuria

Major congenital anomalies were reported in about 4% of infants overall and 5% among infants born to mothers diagnosed with T2DM

POPs are mainly excreted through conjugation with GSH and this mechanism is extremely important for the health status, since exposure to POPs has been associated to diabetes, cardiovascular diseases and many other chronic diseases ( ROS production can occur at several intracellular sites but, for most cells, takes place in the mitochondria and the mitochondrial electron transport chain is the main cellular process of ROS generation in physiological circumstances ( 2 O 2 )