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Even when the main compound patent expires, generic competitors must navigate a growing web of patents, making litigation and the delay of any market entry almost inevitable

However, MTHFR mutations are inherited, so a mutated copy of the genes was likely inherited from parents

doi: 10.18632/oncotarget.3524 35 KhinZPRibeiroMLCJacobsonTHazlehurstLPerezLBazRet al

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Our mechanistic investigations revealed that intracellular GSSG elevation sensitizes hepatocytes to TNF killing by inducing IKK--SSG formation, leading to suppressed NF-B activation

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