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These references make clear that B12 therapy is primarily about treating deficiency, not directly burning fat

The cycling protocols commonly recommended are partly based on this theoretical concern, though actual tolerance development has not been documented

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But that peripheral-only action means it does not suppress appetite, does not change energy expenditure through central pathways, and does not produce the dramatic caloric deficits that GLP-1 agonists like semaglutide or tirzepatide create

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For researchers, the choice between them is straightforward once you know what you're trying to study